Clone:
REA186
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2

Specifications for ERK2 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA186 recognizes ERK2, a 42 KDa serine/threonine protein kinase, which participates in the MAPK signal transduction pathway. It is involved in regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. ERK2 and the related kinase ERK1 are phosphorylated by kinases MEK1/2, leading to activation and nuclear translocation of ERKs, where they phosphorylate downstream targets, such as transcription factors including Ets, Elk, and c-Fos. ERK2 activation and mobilization is induced in reponse to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein–coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to proline residue.
Additional Information: Clone REA186 displays negligible binding to Fc receptors.

Alternative names

MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2

Detailed product information

Technical specifications

CloneREA186
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenERK2
Alternative names of antigenMAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2
Molecular mass of antigen [kDa]41
Entrez Gene ID5594
RRIDAB_2651671, AB_2651672, AB_2651673, AB_2651674, AB_2651675, AB_2651670

Resources for ERK2 Antibody, anti-human/mouse, REAfinity™

Certificates

Please follow this
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References for ERK2 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42(4): 459-467
  2. Roskoski, R. et al. (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66(2): 105-143
  3. Lloyd, A. C. (2006) Distinct functions for ERKs? J. Biol. 5(5): 13
  4. Gonzalez-Perez, G. and Lamousé-Smith, E. S. (2017)
    Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
    +
    T cell receptor signaling.
    Front Immunol 8(8): 265

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