Clone:
REA154
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CLEC7A, BGR, CLECSF12, Beta-GR, βGR

Specifications for Dectin-1 Antibody, anti-mouse, REAfinity™

Overview

Clone REA154 recognizes murine dectin-1, which is approximately 40 kDa type II transmembrane protein, also known as mouse beta-glucan receptor or CLEC7A. It promotes the phagocytosis of intact yeasts and glucan particles such as β-1,3-linked and β-1,6-glucans, thus playing an important role in anti-fungal immunity. Neutrophils and macrophages express relatively higher levels of dectin-1 as compared to dendritic cells and subpopulation of T cells. In cooperation with TLR2 and TLR4, dectin-1 leads to cytokine production in human macrophages and monocytes.
Additional information: Clone REA154 displays negligible binding to Fc receptors.

Alternative names

CLEC7A, BGR, CLECSF12, Beta-GR, βGR

Detailed product information

Technical specifications

CloneREA154
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenDectin-1
Alternative names of antigenCLEC7A, BGR, CLECSF12, Beta-GR, βGR
Molecular mass of antigen [kDa]27
Distribution of antigenT cells, dendritic cells, macrophages
Entrez Gene ID56644
RRIDAB_2651540, AB_2651541, AB_2651542, AB_2651543, AB_2651544, AB_2651545, AB_2651546, AB_2651547, AB_2651548, AB_2651539

Resources for Dectin-1 Antibody, anti-mouse, REAfinity™

Certificates

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References for Dectin-1 Antibody, anti-mouse, REAfinity™

Publications

  1. Taylor, P. R. et al. (2002) The beta-glucan receptor, Dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 169: 3876-3882
  2. Brown, G. D. et al. (2002) Dectin-1 is a major β-glucan receptor on macrophages. J. Exp. Med. 196(3): 407-412
  3. Ferwerda, G. et al. (2008) Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell. Microbiol. 10(10): 2058-2066
  4. Ariizumi, K. et al. (2000) Identification of a novel, dendritic cell-associated molecule, Dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 275: 20157-20167

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