Clone:
REA702
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Cyt c

Specifications for Cytochrome c Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA702 recognizes the human, mouse, and rat cytochrome c, a 15 kDa hemeprotein located in the intermembrane of the mitochondrion. Cytochromes are involved in cell respiration, photosynthesis, and other biochemical reactions. Cytochrome c plays also a role in apoptosis, by release to cytoplasma and binding Apaf-1 which activates procaspase 9. Cytochrome c is found in plants, animals, and many unicellular organisms and catalyzes the electron transfer from reduced cytochrome c to oxygen.
Additional information: Clone REA702 displays negligible binding to Fc receptors.

Alternative names

Cyt c

Detailed product information

Technical specifications

CloneREA702
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenCytochrome c
Alternative names of antigenCyt c
Molecular mass of antigen [kDa]12(same molecular weight for human and mouse/rat)
Distribution of antigenubiquitous
Entrez Gene ID54205, 13063, 25309
RRIDAB_2651485, AB_2651486, AB_2651487, AB_2651488, AB_2651489, AB_2651484

Resources for Cytochrome c Antibody, anti-human/mouse/rat, REAfinity™

Certificates

Please follow this
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References for Cytochrome c Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Margoliash, E. (1963) Primary structure and evolution of cytochrome c. Proc. Natl. Acad. Sci. U.S.A. 50: 672-679
  2. Ferguson, H. A. et al. (2003) UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance. J. Biol. Chem. 278(46): 45793-45800
  3. Tafani, M. et al. (2002) Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J. Biol. Chem. 277(12): 10073-10082

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