Clone:
REA951
Type of antibody:
Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC

Specifications for Cyclin A2 Antibody, anti-human, REAfinity™

Overview

Clone REA951 recognizes the human protein cyclin A2, which belongs to the cyclin family, that members function as regulators for the activity of the cyclin-dependent protein kinases. Cyclin A plays a role in the regulation of the cell cycle and is important for S and M phase, thus cyclin A is used as a marker for actively proliferating cells and for cells in S phase. It is found in dividing cells, e.g., several leukemic cell lines as well as in testis and brain. Clone REA951 does not cross-react with other cyclins or cyclin A1.
Additional information: Clone REA951 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA951
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyRecombinant antibodies
Specieshuman
AntigenCyclin A2
Molecular mass of antigen [kDa]34
Distribution of antigentumor cells, leukemia cells, brain, testicle
Entrez Gene ID890
RRIDAB_2727174, AB_2727196, AB_2727175, AB_2727197, AB_2727176, AB_2727198, AB_2727177, AB_2727195

Resources for Cyclin A2 Antibody, anti-human, REAfinity™

Certificates

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References for Cyclin A2 Antibody, anti-human, REAfinity™

Publications

  1. Pagano, M. et al. (1992) Cyclin A is required at two points in the human cell cycle. EMBO J. 11(3): 961-971
  2. Furuno, N. et al. (1999) Human cyclin A is required for mitosis until mid prophase. J. Cell Biol. 147(2): 295-306
  3. Geley, S. et al. (2001) Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J. Cell Biol. 153(1): 137-148

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