Clone:
REAL352
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Specifications for CD57 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL352 is an antibody fragment derived from the full CD57 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL352 recognizes the human CD57 antigen. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of NK and T cells, but not on erythrocytes, monocytes, granulocytes, or platelets. CD57 expression can be also found on a variety of neural cell types. CD57 has been shown to be expressed on late stage effector CD8
+
T cells. The frequency of CD57
+
T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+
T cells in persistent viral infections, such as HIV. CD57 is a helpful marker to differentiate between Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and T-cell/histiocyte-rich B-cell lymphoma (T/HRBCL).
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Detailed product information

Technical specifications

CloneREAL352
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD57
Alternative names of antigenB3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1
Distribution of antigenB cells, NK cells, T cells, other, ES and iPS cells, other, brain, tonsil

Resources for CD57 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD57 Antibody, anti-human, REAdye_lease™

Publications

  1. Brenchley, J. M. et al. (2003)
    Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8
    +
    T cells.
    Blood 101: 2711-2720
  2. Boudová, L. et al. (2003) Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma. Blood 102(10): 3753-3758
  3. Muntasell, A. et al. (2019) High Numbers of Circulating CD57(+) NK Cells Associate with Resistance to HER2-Specific Therapeutic Antibodies in HER2(+) Primary Breast Cancer. Cancer Immunol Res. 7(8): 1280-1292
  4. Lian, J. et al. (2020) Immunosenescence: a key player in cancer development. J Hematol Oncol. 13(1): 151

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