Clone:
REA1231
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CR, CROM, DAF, TC

Specifications for CD55 (DAF) Antibody, anti-human, REAfinity™

Overview

Clone REA1231 recognizes the human CD55 antigen, a 70 kDa glycosylphosphatidylinositol-anchored single chain glycoprotein, which is also known as complement decay-accelerating factor (DAF). CD55 is broadly distributed among hematopoietic and non-hematopoietic cells. It is expressed on the plasma membranes of all cell types that are in intimate contact with serum and on the surfaces of epithelial cells lining the extracellular compartments. Variants of the molecule are present in body fluids and in extracellular matrix. CD55 plays multiple physiologic roles including tissue protection from the cytotoxic complement injury, anti-inflammatory function owing to its anti-adherence properties which enhance transmigration of monocytes and macrophages and reduce tissue injury. CD55 plays an essential role during pregnancy and is involved in the protection of the semiallogeneic fetus and in preventing uncontrolled infiltration by white cells. It is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes.
Additional information: Clone REA1231 displays negligible binding to Fc receptors.

Alternative names

CR, CROM, DAF, TC

Detailed product information

Technical specifications

CloneREA1231
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD55 (DAF)
Alternative names of antigenCR, CROM, DAF, TC
Molecular mass of antigen [kDa]35
Distribution of antigenB cells, T cells, monocytes, NK cells, epithelial cells
Entrez Gene ID1604
RRIDAB_2877009, AB_2877010, AB_2877019, AB_2877020, AB_2876950, AB_2876951, AB_2877025, AB_2877026, AB_2876962, AB_2876963, AB_2876999, AB_2876936, AB_2876937, AB_2876998

References for CD55 (DAF) Antibody, anti-human, REAfinity™

Publications

  1. Caras, I. W. et al. (1987) Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins. Nature 325(6104): 545-549
  2. Osuka, F. et al. (2006) Molecular cloning and characterization of novel splicing variants of human decay-accelerating factor. Genomics 88(3): 316-322
  3. Nowicki, B. et al. (2013) DAF as a therapeutic target for steroid hormones: implications for host-pathogen interactions. Adv. Exp. Med. Biol. 734: 83-96

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