Clone:
REA1211
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, 3D-IF, IF, IHC
Alternative names:
L3T4, T4, Leu-3, Ly-4

Specifications for CD4 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1211 recognizes the mouse CD4 antigen, a cell surface glycoprotein, which is a member of the immunoglobulin superfamily. It is also known as L3T4 or Leu-3. In mice, CD4 is expressed on T helper cells, regulatory T cells, and at lower levels on subpopulations of NKT cells and dendritic cells. It is furthermore detected on most thymocytes (CD4
+
CD8
+
and CD4
+
CD8
thymocytes). CD4 interacts with MHC class II molecules on the surface of antigen presenting cells. It increases the avidity of the interaction between T cells and antigen-presenting or target cells.
Additional information: Clone REA1211 displays negligible binding to Fc receptors.

Alternative names

L3T4, T4, Leu-3, Ly-4

Detailed product information

Technical specifications

CloneREA1211
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD4
Alternative names of antigenL3T4, T4, Leu-3, Ly-4
Molecular mass of antigen [kDa]48
Distribution of antigenT cells, endothelial cells, NKT cells, T helper cells, regulatory T cells
Entrez Gene ID12504
RRIDAB_2811460, AB_2811461, AB_2811462, AB_2811463, AB_2811464, AB_2811465, AB_2811466, AB_2811467, AB_2811468, AB_2811459

Resources for CD4 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD4 Antibody, anti-mouse, REAfinity™

Publications

  1. Tourvieille, B. et al. (1986) Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science 234(4776): 610-614
  2. Bierer, B. E. et al. (1989) The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu. Rev. Immunol. 7: 579-599
  3. Parnes, J. R. et al. (1987) L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. Immunol. Rev. 100: 109-127

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