Clone:
ES8-20E6
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
KDR, Flk1, VEGFR, VEGFR2

Specifications for CD309 (VEGFR-2) Antibody, anti-human

Overview

The CD309 antibody recognizes the CD309 antigen, a transmembrane tyrosine kinase, and is also known as vascular endothelial growth factor receptor-2 (VEGFR-2) or kinase insert domain–containing receptor (KDR). CD309 is a high-affinity receptor for VEGF and plays a role in hematopoiesis. It is also involved in angiogenesis, both during embryogenesis and in the context of homeostatic or pathological events, e.g., vascularization of tumors. It has been identified on a subset of hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), as well as on their common progenitor, the hemangioblast. CD309 expression is also found on mature endothelial cells (ECs).

Alternative names

KDR, Flk1, VEGFR, VEGFR2

Detailed product information

Technical specifications

CloneES8-20E6
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD309 (VEGFR-2)
Alternative names of antigenKDR, Flk1, VEGFR, VEGFR2
Molecular mass of antigen [kDa]149
Distribution of antigenendothelial cells, megakaryocytes, platelets, stem cells, ES and iPS cells, pancreas, smooth muscle
Entrez Gene ID3791
RRIDAB_2857531, AB_2752160, AB_2752110, AB_10828820, AB_2752111, AB_2801778, AB_2801769, AB_2784123, AB_2784122, AB_2857532, AB_2752161

Resources for CD309 (VEGFR-2) Antibody, anti-human

Certificates

Please follow this
link
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References for CD309 (VEGFR-2) Antibody, anti-human

Publications

  1. Shalaby, F. et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66
  2. Eichmann, A. et al. (1997) Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic Proc. Natl. Acad. Sci. U.S.A. 94: 5141-5146
  3. Flamme, I. et al. (1995) Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo. Dev. Biol. 169: 699-712
  4. Auerbach, R. et al. (1996) Hematopoietic stem cells in the mouse embryonic yolk sac. Stem Cells 14: 269-280

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