Clone:
REA109
Type of antibody:
Primary antibodies, Recombinant antibodies, Functional-grade antibodies
Isotype:
recombinant human IgG1
Applications:
FC, FA, MC
Alternative names:
TLR2, TIL4, Ly105

Specifications for CD282 (TLR2) Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA109 recognises human and mouse CD282, also known as toll-like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type 1 transmembrane proteins with extracellular leucine-rich repeats and intracellular toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram
+
and Gram
bacteria, lipoteichoic acid (LTA) in Gram
+
bacteria, lipoarabinomannan and lipomannan from Mycoplasma, and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and tri-acylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial, and epithelial cells.
Additional information: Clone REA109 displays negligible binding to Fc receptors.

Alternative names

TLR2, TIL4, Ly105

Detailed product information

Technical specifications

CloneREA109
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies, Functional-grade antibodies
Speciesmouse, human
AntigenCD282 (TLR2)
Alternative names of antigenTLR2, TIL4, Ly105
Molecular mass of antigen [kDa]88
Entrez Gene ID7097
RRIDAB_2656979, AB_2656969, AB_2656970, AB_2656973, AB_2656974, AB_2656977, AB_2656978, AB_2751976, AB_2661336, AB_2752006

References for CD282 (TLR2) Antibody, anti-human/mouse, REAfinity™

Publications

  1. Kang, J. Y. et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31(6): 873-884
  2. Takeda, K. and Akira, S. (2005) Toll-like receptors in innate immunity. Int. Immunol. 17: 1-14
  3. Kirschning, C. J. and Schumann, R. R. (2002) TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr Top Microbiol Immunol. 270: 121-144

Related products for
CD282 (TLR2) Antibody, anti-human/mouse, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?