Clone:
REA985
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Specifications for CD273 (PD-L2) Antibody, anti-human, REAfinity™

Overview

Clone REA985 recognizes the human CD273 antigen, also known as B7-DC or PD-L2. CD273 with an approximate molecular weight of 29 kDa is a type I transmembrane protein, belonging to the B7 family of protein ligands and to the Ig superfamily. CD273 is mainly expressed on dendritic cells (DCs) and activated macrophages. It has been shown to interact with programmed-death-receptor 1 (PD-1). A stimulatory as well as a inhibitory role of CD273 in T cell activation has been proposed.
Additional information: Clone REA985 displays negligible binding to Fc receptors.

Alternative names

PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Detailed product information

Technical specifications

CloneREA985
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD273 (PD-L2)
Alternative names of antigenPDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2
Molecular mass of antigen [kDa]29
Distribution of antigendendritic cells, macrophages
Entrez Gene ID80380
RRIDAB_2727605, AB_2727651, AB_2727606, AB_2727652, AB_2727607, AB_2727656, AB_2727611, AB_2727653, AB_2727608, AB_2727654, AB_2727609, AB_2727655, AB_2727610, AB_2801925, AB_2727650

Resources for CD273 (PD-L2) Antibody, anti-human, REAfinity™

Certificates

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References for CD273 (PD-L2) Antibody, anti-human, REAfinity™

Publications

  1. Tseng, S. Y. et al. (2001)
    B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
    J. Exp. Med. 193: 839-846
  2. Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548
  3. Pfistershammer, K. et al. (2006) No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur. J. Immunol. 36(5): 1104-1113

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