Clone:
REAL173
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC, MICS, IHC, IF
Alternative names:
S152, TNFRSF7, Tp55, T14, S152. LPFS2

Specifications for CD27 Antibody, anti-human,
REAlease
®

Overview

Clone REAL173 is an antibody fragment derived from the full CD27 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL173 recognizes the human CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)–induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on NK, T, and B cell populations. The majority of CD4
+
and CD8
+
naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27
+
B cells display all the functional and phenotypic characteristics of memory cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

S152, TNFRSF7, Tp55, T14, S152. LPFS2

Detailed product information

Technical specifications

CloneREAL173
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitymouse
AntigenCD27
Alternative names of antigenS152, TNFRSF7, Tp55, T14, S152. LPFS2
Distribution of antigenNK cells, T cells, B cells, CD4+ T cells, CD8+ T cells
RRIDAB_2751318, AB_2751312, AB_2784098

Resources for CD27 Antibody, anti-human,
REAlease
®

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD27 Antibody, anti-human,
REAlease
®

Publications

  1. Camerini, D. et al. (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J. Immunol. 147(9): 3165-3169
  2. Gravestein, L. A. et al. (1993) Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur. J. Immunol. 23(4): 943-950
  3. Prasad, K. V. et al. (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc. Natl. Acad. Sci. U.S.A. 94(12): 6346-6351

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CD27 Antibody, anti-human,
REAlease
®

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