Clone:
H194-112
Type of antibody:
Primary antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC
Alternative names:
Dpp4, THAM, DPP IV

Specifications for CD26 Antibody, anti-mouse

Overview

Clone H194-112 recognizes the mouse CD26 antigen, a 220 kDa single-pass type II membrane protein also known as dipeptidyl peptidase 4 (Dpp4) or thymocyte-activating molecule (THAM). CD26 is a multifunctional glycoprotein expressed both as a soluble form in plasma and on the surface of several cell types, including epithelial and endothelial cells. In the immune system CD26 is expressed on thymocytes, activated T cells, B cells, NK cells, and macrophages. It has been involved in T cell costimulation, tumor suppression, and adenosine deaminase binding. In addition, CD26 is a serine protease belonging to a subgroup of prolyl oligopeptidases, whose members specifically cleave off N-terminal dipeptides from proteins having proline or alanine in amino acid position 2. The biological activity of several hormones and chemokines can be abolished by CD26
in vitro
. Thus, CD26 has been implicated in the regulation of immune, inflammatory, nervous, and endocrine functions.

Alternative names

Dpp4, THAM, DPP IV

Detailed product information

Technical specifications

CloneH194-112
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD26
Alternative names of antigenDpp4, THAM, DPP IV
Molecular mass of antigen [kDa]87(refers to membrane-bound form)
Distribution of antigenendothelial cells, epithelial cells, B cells, T cells, macrophages, NK cells, thymocytes
Entrez Gene ID13482
RRIDAB_2656721, AB_2656722, AB_2656727, AB_2656728, AB_2656729, AB_2656730, AB_2733793

Resources for CD26 Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD26 Antibody, anti-mouse

Publications

  1. Marguet, D. et al. (2000) Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc. Natl. Acad. Sci. U.S.A. 97(12): 6874-6879
  2. Marguet, D. et al. (1992) cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J. Biol. Chem. 267(4): 2200-2208
  3. Matteucci, E. et al. (2009) Dipeptidyl peptidase-4 (CD26): knowing the function before inhibiting the enzyme. Curr. Med. Chem. 16(23): 2943-2951

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