Clone:
REA388
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CD244, 2B4, C9.1, Ly90, NAIL, NKR2B4, Nmrk, SLAMF4, 2B4 B6 Alloantigen

Specifications for CD244.2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA388 recognizes an alloantigen of the mouse CD244 antigen, a Single-pass type I membrane protein also known as 2B4. CD244 is a receptor belonging to the CD2 subfamily of the Ig superfamily and is involved in non-MHC dependent cytotoxicity. Expression of CD244 is found on all NK cells, γδ T cells, basophils, and monocytes as well as a subset of memory-phenotype CD8
+
αβ T cells. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. CD244 is primarily involved in inhibiting NK cell functions. In inbred mice, at least two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. Clone REA388 reacts with CD244.2, the CD244 allloantigen which is expressed on C57BL/6 and C58/J mice, but not in Balb/c mice.
Additional information: Clone REA388 displays negligible binding to Fc receptors.

Alternative names

CD244, 2B4, C9.1, Ly90, NAIL, NKR2B4, Nmrk, SLAMF4, 2B4 B6 Alloantigen

Detailed product information

Technical specifications

CloneREA388
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD244.2
Alternative names of antigenCD244, 2B4, C9.1, Ly90, NAIL, NKR2B4, Nmrk, SLAMF4, 2B4 B6 Alloantigen
Molecular mass of antigen [kDa]43
Distribution of antigenNK cells, T cells, monocytes
Entrez Gene ID18106
RRIDAB_2656626, AB_2656627, AB_2656628, AB_2656629, AB_2656630, AB_2656631, AB_2656632, AB_2656633, AB_2656634, AB_2656635, AB_2656636, AB_2656637

Resources for CD244.2 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD244.2 Antibody, anti-mouse, REAfinity™

Publications

  1. Mathew, P. A. et al. (1993) Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J. Immunol. 151(10): 5328-5337
  2. Kumaresan, P. R. et al. (2000) Polymorphism in the 2B4 gene of inbred mouse strains. Immunogenetics 51(8-9): 758-761
  3. McNerney, M. E. et al. (2005)
    2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8
    +
    T cells.
    Mol. Immunol. 42(4): 489 -494

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CD244.2 Antibody, anti-mouse, REAfinity™

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