Clone:
REA354
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CCR5, AM4-7, CD195, CMKBR5

Specifications for CD195 (CCR5) Antibody, anti-mouse, REAfinity™

Overview

Clone REA354 recognizes the mouse CD195 antigen, a multi-pass membrane protein which is also known as C-C chemokine receptor type 5 (CCR5). CD195 belongs to the G-protein coupled receptor 1 family and is predominantly expressed on T cells, macrophages, dendritic cells, and microglia. It is a receptor for a number of inflammatory CC-chemokines including MIP-1-α, MIP-1-β, and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. CD195 is involved in the chemotaxis of leucocytes to inflammation sites and plays an important role in the recruitment of macrophages, T cells, and monocytes in inflammation. Additionally, CCR5 may have an indirect effect on cancer progression by controlling the antitumor immune response, since it has been demonstrated that its expression could promote tumor growth and contribute to tumor metastasis.
Additional information: Clone REA354 displays negligible binding to Fc receptors.

Alternative names

CCR5, AM4-7, CD195, CMKBR5

Detailed product information

Technical specifications

CloneREA354
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD195 (CCR5)
Alternative names of antigenCCR5, AM4-7, CD195, CMKBR5
Molecular mass of antigen [kDa]41
Distribution of antigenmacrophages, microglia, dendritic cells, thymocytes
Entrez Gene ID12774
RRIDAB_2801746, AB_2819437, AB_2857757, AB_2655920, AB_2655921, AB_2801755

Resources for CD195 (CCR5) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD195 (CCR5) Antibody, anti-mouse, REAfinity™

Publications

  1. Barashi, N. et al. (2013) Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice. Hepatology 58(3): 1021-1030
  2. Meyer, A. et al. (1996) Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. J. Biol. Chem. 271(24): 14445-14451
  3. Doranz, B. J. et al. (1997) Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J. Virol. 71(9): 6305-6314

Related products for
CD195 (CCR5) Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?