Clone:
REA1171
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FasL, APT1LG1, CD95L, TNFSF6, gld

Specifications for CD178 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1171 recognizes the type II transmembrane glycoprotein mouse CD178, also known as Fas Ligand, FasL, or CD95 Ligand, which is a 40 kDa member of the TNF cytokine family expressed on activated lymphocytes such as T cells, NK cells, or monocytes as well as in immune-privilaged sites, e.g, cornea or testis. CD178 can trigger apoptosis through trimerization of the Fas receptor CD95. Thereby, CD178 and CD95 play a key role in the regulation of the immune system. Cleavage of membrane bound CD178 from the cell surface via matrix metalloproteinases (such as MMP-7) generates soluble CD178 molecules.
Additional information: Clone REA1171 displays negligible binding to Fc receptors.

Alternative names

FasL, APT1LG1, CD95L, TNFSF6, gld

Detailed product information

Technical specifications

CloneREA1171
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD178
Alternative names of antigenFasL, APT1LG1, CD95L, TNFSF6, gld
Molecular mass of antigen [kDa]31
Distribution of antigenmonocytes, NK cells, T cells
Entrez Gene ID14103
RRIDAB_2784010, AB_2784013, AB_2784012, AB_2784015, AB_2784014, AB_2784017, AB_2784016, AB_2784009, AB_2784008, AB_2784011

Resources for CD178 Antibody, anti-mouse, REAfinity™

Certificates

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References for CD178 Antibody, anti-mouse, REAfinity™

Publications

  1. Takahashi, T. et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76(6): 969-976
  2. Oyaizu, N. et al. (1997)
    Monocytes express Fas ligand upon CD4 cross-linking and induce CD4
    +
    T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.
    J. Immunol. 158: 2456 -2463
  3. Kayagaki, N. et al. (1997) Polymorphism of murine Fas ligand that affects the biological activity. Proc. Natl. Acad. Sci. U.S.A. 94: 3914 -3919
  4. Janssen, O. et al. (2003) CD95 ligand – death factor and costimulatory molecule? Cell Death Differ. 10(11): 1215-1225

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