Clone:
VEP13
Type of antibody:
Primary antibodies
Isotype:
mouse IgMκ
Applications:
FC
Alternative names:
FcγRIIIA, FcγRIIIB, FcR-10, IGFR3, IMD20

Specifications for CD16 Antibody, anti-human

Overview

CD16 is a 50–80 kDa glycoprotein that is expressed in two different isoforms. The transmembrane form is found on human NK cells, macrophages, and mast cells, while the glycosylphosphatidylinositol (GPI)-linked form is present on neutrophils.
The human CD16 antigen is a low-affinity receptor for aggregated IgG. The transmembrane form plays a role in signal transduction, NK cell activation, and antibody-dependent cellular cytotoxicity. Clone VEP13 recognizes both the extracellular domain of the transmembrane form as well as the GPI-linked form of the human CD16 antigen. CD16 is expressed on the majority of rhesus monkey NK cells and on a subset of monocytes but not on granulocytes.

Alternative names

FcγRIIIA, FcγRIIIB, FcR-10, IGFR3, IMD20

Detailed product information

Technical specifications

CloneVEP13
Clonalitymonoclonal
Isotypemouse IgMκ
Isotype controlIsotype Control Antibody, mouse IgM
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenCD16
Alternative names of antigenFcγRIIIA, FcγRIIIB, FcR-10, IGFR3, IMD20
Molecular mass of antigen [kDa]20-27
Distribution of antigenT cells, NK cells, macrophages, monocytes, mast cells, myeloid leukemia cells, granulocytes, eosinophils, neutrophils, thymocytes
Entrez Gene ID2214
RRIDAB_2726148, AB_2661279, AB_2726425

References for CD16 Antibody, anti-human

Publications

  1. Schlaepfer, E. et al. (2008)
    Anti-HIV activity mediated by natural killer and CD8
    +
    cells after toll-like receptor 7/8 triggering.
    PLoS One 3(4): e1999

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