Clone:
REA779
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1

Specifications for CD135 (FLT3) Antibody, anti-mouse, REAfinity™

Overview

Clone REA779 recognizes the mouse CD135 antigen, a 150 kDa surface protein Fms-like tyrosine kinase receptor 3 (FLT3), also known as FLK-2. CD135 has functional and structural homology to the class III–receptor tyrosine kinases that include the M-CSF-, KIT-, and PDGF-receptors. The receptor is expressed on progenitor cells in adult bone marrow, thymus, brain, testis, and placenta. All hematopoietic cells develop from CD135 negative hematopoietic stem cells (HSCs) through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the proliferation and differentiation of primitive hematopoietic stem cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.
Additional information: Clone REA779 displays negligible binding to Fc receptors.

Alternative names

FLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1

Detailed product information

Technical specifications

CloneREA779
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD135 (FLT3)
Alternative names of antigenFLT3, FLK-2, Ly72, wmfl, Flt3/Flk2, STK-1
Molecular mass of antigen [kDa]110
Distribution of antigenB cells, stem cells, hematopoietic stem and progenitor cells, bone marrow, brain, lung, spleen
Entrez Gene ID14255
RRIDAB_2654952, AB_2654953, AB_2654954, AB_2654955, AB_2654956, AB_2654957, AB_2654958, AB_2654951

Resources for CD135 (FLT3) Antibody, anti-mouse, REAfinity™

Documents and Protocols

Certificates

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References for CD135 (FLT3) Antibody, anti-mouse, REAfinity™

Publications

  1. Hannum, C. et al. (1994) Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs. Nature 368(6472): 643-648
  2. Ogawa, M. et al. (1998) Flt3/Flk-2 and c-Kit are not essential for the proliferation of B lymphoid progenitor cells in the bone marrow of the adult mouse. Exp. Hematol. 26(6): 478-488
  3. Waskow, C. et al. (2008) The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat. Immunol. 9(6): 676-683
  4. Auffray, C. et al. (2009)
    CX
    3
    CR1
    +
    CD115
    +
    CD135
    +
    common macrophage/DC precursors and the role of CX
    3
    CR1 in their response to inflammation.
    J. Exp. Med. 206(3): 595-606
  5. Böiers, C. et al. (2010) Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development. Blood 115(24): 5061-5068
  6. Boyer, S. W. et al. (2011) All hematopoietic cells develop from hematopoietic stem cells through Flk2/Flt3-positive progenitor cells. Cell Stem Cell 9(1): 64-73

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