Clone:
REA1015
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ

Specifications for CD122 (IL-2Rβ) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1015 recognizes the murine CD122 70–75 kDa cell surface glycoprotein, also known as interleukin-2 receptor beta chain (IL-2Rβ). CD122 is constitutively expressed on mouse NK cells and at a lower level on subsets of T cells, B cells, monocytes, and macrophages. CD122 can associate with the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25), resulting in intermediate or high affinity IL-2 receptor complexes. CD122 expression levels can be upregulated by activation. Clone REA1015 interferes with binding of IL-2 to the receptor and can be used to deplete CD122
+
cells.
Additional information: Clone REA1015 displays negligible binding to Fc receptors.

Alternative names

IL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ

Detailed product information

Technical specifications

CloneREA1015
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD122 (IL-2Rβ)
Alternative names of antigenIL2RB, IL-15Rbeta, Il-2/15Rbeta, Il-2Rbeta, p70, IL-2Rβ
Molecular mass of antigen [kDa]58
Distribution of antigenB cells, macrophages, monocytes, NK cells, T cells
Entrez Gene ID16185
RRIDAB_2727816, AB_2727746, AB_2727817, AB_2727747, AB_2727818, AB_2727748, AB_2727819, AB_2727820, AB_2727821, AB_2727749, AB_2727822, AB_2727750

References for CD122 (IL-2Rβ) Antibody, anti-mouse, REAfinity™

Publications

  1. Tanaka, T. et al. (1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL- 4 J. Immunol. 147: 2222-2228
  2. Tang, Y. et al. (2011) Emergence of NK cell progenitors and functionally competent NK cell lineage subsets in the early mouse embryo. Blood 120: 63-75
  3. Malek, T. R. et al. (1995) Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. J. Interferon Cytokine Res. 15(5): 447-454
  4. Nishikawa, Y. et al. (2010)
    Roles of CD122
    +
    cells in resistance against
    Neospora caninum
    infection in a murine model.
    J. Vet. Med. Sci. 72(10): 1275-1282

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