Clone:
REAL151
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC, MICS, IF, IHC
Alternative names:
Itgb4

Extended validation for CD104 (Integrin β4) Antibody, anti-human,
REAlease
®

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REAL151
439-9B++
58XB4-
450-9D mIgG1+
422325 mIgG2b-
REA236++
Cells were incubated with an excess of purified unconjugated CD104 (Integrin β4) (REAL151) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD104 (Integrin β4) Antibody, anti-human,
REAlease
®

Overview

Clone REAL151 is an antibody fragment derived from the full CD104 (Integrin β4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL151 recognizes CD104, which is also known as integrin β4. Integrins are a family of type I transmembrane heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. CD104 interacts with α6 integrin and serves as receptor for laminin and component of hemidesmosomes. Expression of α6β4 integrin is found in the basal aspect of stratified epithelia such as epidermis, stratified squamous epithelium of squamous mucosa, urotheliumin, and certain tumor cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Itgb4

Detailed product information

Technical specifications

CloneREAL151
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD104 (Integrin β4)
Alternative names of antigenItgb4
Distribution of antigenepithelial cells
RRIDAB_2751277, AB_2811372, AB_2811358, AB_2751289, AB_2751281, AB_2783901, AB_2783902, AB_2751285

Resources for CD104 (Integrin β4) Antibody, anti-human,
REAlease
®

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD104 (Integrin β4) Antibody, anti-human,
REAlease
®

Publications

  1. Tuckwell, D. S. et al. (1993) Integrins: a review of their structure and mechanisms of ligand binding. Symp. Soc. Exp. Biol 47: 107-136
  2. Simon-Assmann, P. et al. (1994) Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. Dev. Dyn. 201(1): 71-85

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REAlease
®

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