Clone:
REAL172
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC
Alternative names:
EWI-101, Gm1016, Gm734, IGSF2

Specifications for CD101 Antibody, anti-mouse,
REAlease
®

Overview

Clone REAL172 is an antibody fragment derived from the full CD101 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL172 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as Immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
+
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DC inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
+
CD25
+
regulatory T cells both
in vitro
and
in vivo
.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

EWI-101, Gm1016, Gm734, IGSF2

Detailed product information

Technical specifications

CloneREAL172
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD101
Alternative names of antigenEWI-101, Gm1016, Gm734, IGSF2
Distribution of antigenmonocytes, granulocytes, dendritic cells, T cells
RRIDAB_2751313, AB_2783897, AB_2783896, AB_2751582

Resources for CD101 Antibody, anti-mouse,
REAlease
®

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD101 Antibody, anti-mouse,
REAlease
®

Publications

  1. Penha-Gonçalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52(6): 1551-1556
  2. Fernandez, I. et al. (2007)
    CD101 surface expression discriminates potency among murine FoxP3
    +
    regulatory T cells.
    J. Immunol. 179(5): 2808-2814
  3. Mohammed, J. P. et al. (2011)
    Identification of CD101 as a susceptibility gene for
    Novosphingobium aromaticivorans
    -induced liver autoimmunity.
    J. Immunol. 187(1): 337-349

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CD101 Antibody, anti-mouse,
REAlease
®

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