Clone:
REA872
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, IF, IHC
Alternative names:
BCL2

Specifications for Bcl-2 Antibody, anti-human, REAfinity™

Overview

Clone REA872 recognizes the human Bcl-2 antigen, which is an intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is a member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor.
Additional information: Clone REA872 displays negligible binding to Fc receptors.

Alternative names

BCL2

Detailed product information

Technical specifications

CloneREA872
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenBcl-2
Alternative names of antigenBCL2
Molecular mass of antigen [kDa]26
Distribution of antigenneural cells
Entrez Gene ID596
RRIDAB_2726499, AB_2726570, AB_2726500, AB_2726571, AB_2726501, AB_2726569

Resources for Bcl-2 Antibody, anti-human, REAfinity™

Certificates

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References for Bcl-2 Antibody, anti-human, REAfinity™

Publications

  1. Bruey, J. M. et al. (2007) Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell 129(1): 45-56
  2. Wei, Y. et al. (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell 30(6): 678-688

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