Clone:
REA476
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
EMMPRIN, Basigin (BSG), Neurothelin, 5F7, BSG, TCSF, OKa, CD147

Specifications for TRA-1-85 (CD147) Antibody, anti-human, REAfinity™

Overview

Clone REA476 recognizes the human TRA-1-85 antigen, a single-pass type I membrane protein, which is also known as CD147, basigin, or extracellular matrix metalloproteinase inducer (EMMPRIN). TRA-1-85 is expressed by many cell types, including epithelial cells, endothelial cells, leukocytes, and tumor cells. It is present in vascular endothelium in non-neoplastic regions of the brain, and in tumor cells but not in proliferating blood vessels in malignant gliomas. TRA-1-85 has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer, but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression, and spermatogenesis. TRA-1-85 is often used to discern human cells from non-human cells in multiple applications including animal transplantation studies.
Additional information: Clone REA476 displays negligible binding to Fc receptors.

Alternative names

EMMPRIN, Basigin (BSG), Neurothelin, 5F7, BSG, TCSF, OKa, CD147

Detailed product information

Technical specifications

CloneREA476
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTRA-1-85 (CD147)
Alternative names of antigenEMMPRIN, Basigin (BSG), Neurothelin, 5F7, BSG, TCSF, OKa, CD147
Molecular mass of antigen [kDa]40
Distribution of antigenleukocytes, endothelial cells, epithelial cells, tumor cells
Entrez Gene ID682
RRIDAB_2654232, AB_2654233, AB_2654236, AB_2654237, AB_2654238, AB_2654239, AB_2654240, AB_2654241, AB_2654242, AB_2654243

References for TRA-1-85 (CD147) Antibody, anti-human, REAfinity™

Publications

  1. Biswas, C. et al. (1995) The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55(2): 434-439
  2. Williams, B. P. et al. (1988) Biochemical and genetic analysis of the OKa blood group antigen. Immunogenetics 27(5): 322-329
  3. Yurchenko, V. et al. (2006) Dealing with the family: CD147 interactions with cyclophilins. Immunology 117(3): 301-309

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