Clone:
REA636
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TNFa, TNFalpha, TNF-alpha, Cachectin, Tnfsf1a, TNFSF2

Specifications for TNF-α Antibody, anti-mouse, REAfinity™

Overview

Clone REA636 recognizes the mouse tumor necrosis factor α (TNF-α) antigen, a 17 kDa cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-α is produced by cells that are involved in inflammatory immune responses. It is secreted by activated CD4
+
T cells, monocytes, macrophages, NK cells, and neutrophils. TNF-α binding to surface receptors elicits a wide array of biologic activities, including cytolysis and cytostasis of many tumor cell lines
in vitro
, hemorraghic necrosis of tumors
in vivo
, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. Furthermore it causes fever by direct action or by stimulation of interleukin-1 secretion.
Additional information: Clone REA636 displays negligible binding to Fc receptors.

Alternative names

TNFa, TNFalpha, TNF-alpha, Cachectin, Tnfsf1a, TNFSF2

Detailed product information

Technical specifications

CloneREA636
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTNF-α
Alternative names of antigenTNFa, TNFalpha, TNF-alpha, Cachectin, Tnfsf1a, TNFSF2
Molecular mass of antigen [kDa]26
Distribution of antigenT cells
Entrez Gene ID21926
RRIDAB_2784485, AB_2819466, AB_2784486

References for TNF-α Antibody, anti-mouse, REAfinity™

Publications

  1. Chyuan, I. T. et al. (2015) Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model. Cell. Mol. Immunol. 12(3): 317-325
  2. Torrente, Y. et al. (2003) Tumor necrosis factor-alpha (TNF-alpha) stimulates chemotactic response in mouse myogenic cells. Cell Transplant 12(1): 91-100
  3. Kaiser, G. C. et al. (1997) Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology 112(4): 1231-1240

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