Clone:
REA525
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Specifications for STAT1 pS727 Antibody, anti-human, REAfinity™

Overview

Clone REA525 recognizes the signal transducer and activator of transcription 1 (STAT1) antigen phosphorylated at serine 727 (pS727). STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. STAT1 is an essential transcription factor for macrophage activation by IFN-γ and requires phosphorylation of the C-terminal pS727 for transcriptional activity. It forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes.
Additional information: Clone REA525 displays negligible binding to Fc receptors.

Alternative names

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Detailed product information

Technical specifications

CloneREA525
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSTAT1 pS727
Alternative names of antigenCANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Molecular mass of antigen [kDa]87
Distribution of antigenother
Entrez Gene ID6772
RRIDAB_2653559, AB_2653560, AB_2653561, AB_2653562, AB_2653563, AB_2653558

References for STAT1 pS727 Antibody, anti-human, REAfinity™

Publications

  1. Kovarik, P. et al. (1999) Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 96(24): 13956-13961
  2. Vanhatupa, S. et al. (2008) MAPK-induced Ser727 phosphorylation promotes SUMOylation of STAT1. Biochem. J. 409(1): 179-185
  3. Luu, K. et al. (2014) STAT1 plays a role in TLR signal transduction and inflammatory responses. Immunol. Cell Biol. 92(9): 761-769

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