Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Specifications for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™


Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5.
Additional information: Clone REA393 displays negligible binding to Fc receptors.

Alternative names

CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenCD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14
Molecular mass of antigen [kDa]51
Distribution of antigenmonocytes, granulocytes, dendritic cells, B cells, macrophages
Entrez Gene ID8778, 100049587
RRIDAB_2819695, AB_2653414, AB_2653415, AB_2653418, AB_2653419, AB_2653420, AB_2653421, AB_2905384, AB_2905383, AB_2922164, AB_2922130, AB_2928834, AB_2928833, AB_2819703

Resources for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™


Please follow this
to search for Certificates of Analysis (CoA) by lot number.

References for Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™


  1. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
  2. Ali, S. R. et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J. Exp. Med. 211(6): 1231-1242
  3. Angata, T. et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20(12): 1964-1973

Related products for
Siglec-5/Siglec-14 Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?