Clone:
REA580
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1

Specifications for SHIP-1 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA580 recognizes the human and mouse SHIP-1 antigen, which is a 145 kDa protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP-1, also known as enzyme phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, is expressed on hematopoietic cells, including immature CD34
+
cells, the majority of T cells, and a minority of B cells. It has a negative effect on cell growth and therefore loss or modification may have profound effects on hematopoietic cell development. Thus SHIP-1 functions as a negative regulator of myeloid cell proliferation and survival.
Additional information: Clone REA580 displays negligible binding to Fc receptors.

Alternative names

INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1

Detailed product information

Technical specifications

CloneREA580
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenSHIP-1
Alternative names of antigenINPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1
Molecular mass of antigen [kDa]133, 134(separately shown for human and mouse/rat)
Distribution of antigenB cells, T cells, hematopoietic stem and progenitor cells
Entrez Gene ID3635, 16331
RRIDAB_2653407, AB_2653408, AB_2653409, AB_2653406

References for SHIP-1 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Drayer, A. L. et al. (1996) Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Biochem. Biophys. Res. Commun. 225(1): 243-249
  2. Geier, S. J. et al. (1997) The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood 89(6): 1876-1885
  3. Ware, M. D. et al. (1996) Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood 88(8): 2833-2840

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