Clone:
REA578
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Mrnp41

Specifications for Rae-1α/β/γ Antibody, anti-mouse, REAfinity™

Overview

Clone REA578 recognizes the Rae-1α/β/γ antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1α/β/γ were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells
in vivo
. Clone REA578 does not detect Rae-1δ/ε.
Additional information: Clone REA578 displays negligible binding to Fc receptors.

Alternative names

Mrnp41

Detailed product information

Technical specifications

CloneREA578
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenRae-1α/β/γ
Alternative names of antigenMrnp41
Molecular mass of antigen [kDa]23
Distribution of antigenNK cells, T cells
Entrez Gene ID19368, 19369, 19370
RRIDAB_2653331, AB_2653332, AB_2653333, AB_2653334, AB_2653335, AB_2653336, AB_2653339, AB_2653340

References for Rae-1α/β/γ Antibody, anti-mouse, REAfinity™

Publications

  1. Diefenbach, A. et al. (2001) Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413(6852): 165-171
  2. Diefenbach, A. et al. (2000) Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1(2): 119-126
  3. Nomura, M. et al. (1996) Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. J. Biol. Chem. 120(5): 987-995

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