Clone:
REA156
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, IF, IHC
Alternative names:
PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Specifications for PKCα Antibody, anti-human, REAfinity™

Overview

Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
2+
handling in myocytes.
Additional information: Clone REA156 displays negligible binding to Fc receptors.

Alternative names

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Detailed product information

Technical specifications

CloneREA156
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitymouse, rat, dog, chicken
AntigenPKCα
Alternative names of antigenPRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
Molecular mass of antigen [kDa]77
Distribution of antigenother
Entrez Gene ID5578
RRIDAB_2653209, AB_2653210, AB_2653211, AB_2653212

References for PKCα Antibody, anti-human, REAfinity™

Publications

  1. Koivunen, J. et al. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235(1): 1-10
  2. Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18(8): 2183
  3. Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78(2): 349-355

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