Clone:
REA1188
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CLEC8A, LOX1, hLOX-1, OLR1

Specifications for LOX-1 Antibody, anti-human, REAfinity™

Overview

Clone REA1188 recognizes the human LOX-1 antigen, the lectin-like oxidized LDL receptor 1, which is also known as OLR1 and CLEC8A belonging to the C-type lectin superfamily. LOX-1 is found on on endothelial cells, macrophages, platelets, fibroblasts, and smooth muscle cells. It plays a role in endocytosis, phagocytosis, apoptosis, and inflammatory processes.
Additional information: Clone REA1188 displays negligible binding to Fc receptors.

Alternative names

CLEC8A, LOX1, hLOX-1, OLR1

Detailed product information

Technical specifications

CloneREA1188
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenLOX-1
Alternative names of antigenCLEC8A, LOX1, hLOX-1, OLR1
Molecular mass of antigen [kDa]31
Distribution of antigenendothelial cells, fibroblasts, macrophages, platelets
Entrez Gene ID4973
RRIDAB_2784416, AB_2784415, AB_2784412, AB_2784411, AB_2784419, AB_2784418, AB_2784421, AB_2784420, AB_2784414, AB_2784413, AB_2784423, AB_2784422, AB_2784417

References for LOX-1 Antibody, anti-human, REAfinity™

Publications

  1. Sawamura, T. et al. (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386(6620): 73-77
  2. Draude, G. et al. (1999) The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin. Biochem. Pharmacol. 57(4): 383-386
  3. Pirillo, A. et al. (2013) LOX-1, OxLDL, and atherosclerosis. Mediators Inflamm

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