Clone:
REA298
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
AA4.1, C1QR1, C1qRp, Ly68

Extended validation for CD93 Antibody, anti-mouse, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA298
AA4.1++
Cells were incubated with an excess of purified unconjugated CD93 (REA298) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD93 Antibody, anti-mouse, REAfinity™

Overview

Clone REA298 recognizes the mouse CD93 antigen, C-type lectin like type I transmembrane protein also known as also known as AA4.1 antigen or C1QR1. CD93 is widely expressed on hematopoietic cells such as immature dendritic cells, monocytes and macrophages, and immature B lymphocytes but also on hematopoietic progenitors and stem cells in adult bone marrow, embryonic yolk sac, and fetal liver. It mediates the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and plays a role in intercellular adhesion. CD93 is a marker for early multipotent hematopoietic precursor cells and plays a role in cell-cell interactions during hematopoietic and vascular development. It is also involved in other immunological processes such as enhancement of bacterial phagocytosis, clearance of apoptotic cells, or neutralisation of virus.
Additional information: Clone REA298 displays negligible binding to Fc receptors.

Alternative names

AA4.1, C1QR1, C1qRp, Ly68

Detailed product information

Technical specifications

CloneREA298
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD93
Alternative names of antigenAA4.1, C1QR1, C1qRp, Ly68
Molecular mass of antigen [kDa]67
Distribution of antigenB cells, macrophages, monocytes
Entrez Gene ID17064
RRIDAB_2659606, AB_2659607, AB_2659608, AB_2659609, AB_2659610, AB_2659611, AB_2659612, AB_2659613, AB_2784308

References for CD93 Antibody, anti-mouse, REAfinity™

Publications

  1. Norsworthy, P. J. et al. (2004)
    Murine CD93 (C1qRp) contributes to the removal of apoptotic cells
    in vivo
    but is not required for C1q-mediated enhancement of phagocytosis.
    J. Immunol. 172(6): 3406-3414
  2. Petrenko, O. et al. (1999) The molecular characterization of the fetal stem cell marker AA4. Immunity 10(6): 691-700
  3. Jacque, E. et al. (2015) BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J. Exp. Med. 212: 883-892
  4. Kim, T. S. et al. (2000) Characterization of the murine homolog of C1qR(P): identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qR(P). Mol. Immunol. 37(7): 377-389

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