Clone:
FA-11
Type of antibody:
Primary antibodies
Isotype:
rat IgG2a
Applications:
ICFC, IF, IHC, MICS
Alternative names:
Lamp4, SCARD1, gp110, macrosialin

Specifications for CD68 Antibody, anti-mouse

Overview

The monoclonal antibody FA-11 recognizes mouse CD68, also known as macrosialin, which is a heavily glycosylated type I transmembrane protein of the LAMP (lysosomal-associated membrane protein) family. It is expressed on tissue macrophages, langerhans cells and at a low density on dendritic cells. Murine CD68 is predominantly intracellular but it is reported that 10-15% of CD68 is expressed on the cell surface as well. Macrosialin functions as a macrophage receptor for oxidized low density lipoprotein.

Alternative names

Lamp4, SCARD1, gp110, macrosialin

Detailed product information

Technical specifications

CloneFA-11
Clonalitymonoclonal
Isotyperat IgG2a
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD68
Alternative names of antigenLamp4, SCARD1, gp110, macrosialin
Molecular mass of antigen [kDa]33
Distribution of antigendendritic cells, macrophages, Langerhans cells
Entrez Gene ID12514
RRIDAB_2659046, AB_2659047, AB_2659048, AB_2659049, AB_2659050, AB_2659051, AB_2659052, AB_2659053, AB_2659054, AB_2659055, AB_2659056, AB_2659057, AB_2659058, AB_2659059, AB_2659060, AB_2659061, AB_2727202

Resources for CD68 Antibody, anti-mouse

References for CD68 Antibody, anti-mouse

Publications

  1. Ramprasad, M. P. et al. (1996) Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc. Natl. Acad. Sci. U.S.A. 93: 14833-14838
  2. Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108
  3. Smith, M. J. et al. (1987) Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes. J. Cell. Sci. 87: 113-119
  4. Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60(6): 894-907
  5. G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65(6): 990-1004
  6. Batiuk, M. Y. et al. (2017) An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J. Biol. Chem. 292(21): 8874-8891

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