Clone REAL352 is an antibody fragment derived from the full CD57 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL352 recognizes the human CD57 antigen. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of NK and T cells, but not on erythrocytes, monocytes, granulocytes, or platelets. CD57 expression can be also found on a variety of neural cell types. CD57 has been shown to be expressed on late stage effector CD8
+ T cells. The frequency of CD57
+ T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+ T cells in persistent viral infections, such as HIV. CD57 is a helpful marker to differentiate between Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and T-cell/histiocyte-rich B-cell lymphoma (T/HRBCL).
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
