Clone:
REA807
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA4, Itga4B, VLA-4α, Integrin alpha-4

Specifications for CD49d Antibody, anti-mouse, REAfinity™

Overview

Clone REA807 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1).
Additional information: Clone REA807 displays negligible binding to Fc receptors.

Alternative names

ITGA4, Itga4B, VLA-4α, Integrin alpha-4

Detailed product information

Technical specifications

CloneREA807
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD49d
Alternative names of antigenITGA4, Itga4B, VLA-4α, Integrin alpha-4
Molecular mass of antigen [kDa]111
Distribution of antigenB cells, dendritic cells, Langerhans cells, lymphocytes, macrophages, mast cells, monocytes, myeloid leukemia cells, NK cells, red blood cells, T cells, basophils, eosinophils, thymocytes, cardiac muscle, placenta, skeletal muscle, smooth muscle
Entrez Gene ID16401
RRIDAB_2658514, AB_2658515, AB_2658516, AB_2658517, AB_2658518, AB_2751062, AB_2751056, AB_2658519, AB_2658520, AB_2658513

References for CD49d Antibody, anti-mouse, REAfinity™

Publications

  1. Berlin, C. et al. (1993) Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74(1): 185-195
  2. Fogler, W. E. et al. (1996) NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156(12): 4707-4714

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