Clone:
REA1194
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ITGA2B, GPalpha IIb, GPIIb

Specifications for CD41 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1194 recognizes the mouse CD41 antigen, a single-pass type I membrane protein also known as integrin α2b or GPIIb. CD41 associates with CD61 to form the heterodimeric gpIIb/gpIIIa complex that is present on megakaryocytes, platelets, and early hematopoietic progenitors. The CD41/CD61 complex is a receptor for several adhesion molecules such as fibronectin, fibrinogen, plasminogen, and vitronectin and mediates platelets aggregation. CD41 expression marks the divergence of definitive hematopoietic precursors from the hemangioblasts or hemogenic endothelium during mouse embryonic development.
Additional information: Clone REA1194 displays negligible binding to Fc receptors.

Alternative names

ITGA2B, GPalpha IIb, GPIIb

Detailed product information

Technical specifications

CloneREA1194
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD41
Alternative names of antigenITGA2B, GPalpha IIb, GPIIb
Molecular mass of antigen [kDa]109
Distribution of antigenmegakaryocytes, platelets, hematopoietic stem and progenitor cells
Entrez Gene ID16399
RRIDAB_2801927, AB_2801928, AB_2801929, AB_2801930, AB_2801931, AB_2801932, AB_2801933, AB_2801926

References for CD41 Antibody, anti-mouse, REAfinity™

Publications

  1. Mikkola, H. K. et al. (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101(2): 508-516
  2. Thornton, M. A. et al. (1999) Characterization of the murine platelet alphaIIb gene and encoded cDNA. Blood 94(11): 3947-3950
  3. Chen, Y. Q. et al. (1992) Identification of the alpha IIb beta 3 integrin in murine tumor cells. J. Biol. Chem. 267(24): 17314-17320