Clone:
REA271
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IGF1R, IGFIR, IGFR, JTK13

Specifications for CD221 (IGF-1R) Antibody, anti-human, REAfinity™

Overview

Clone REA271 recognizes human CD221 (IGF-1R), a widely expressed cell-surface glycoprotein composed of two α subunits and two β subunits. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain. The α chains are located extracellularly, while the β subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF-1R is activated by binding of its ligands insulin-like growth factor 1 (IGF-1), IGF-2, as well as insulin to the extracellular α subunits. Ligand binding leads to autophosphorylation of tyrosine residues in the cytoplasmic regions of the receptor β subunits and subsequent recruitment and phosphorylation of insulin receptor substrate (IRS) proteins. This finally results in activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells exhibit altered IGF-1R expression.
Additional information: Clone REA271 displays negligible binding to Fc receptors.

Alternative names

IGF1R, IGFIR, IGFR, JTK13

Detailed product information

Technical specifications

CloneREA271
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD221 (IGF-1R)
Alternative names of antigenIGF1R, IGFIR, IGFR, JTK13
Molecular mass of antigen [kDa]151(sum of molecular weights of subunits)
Entrez Gene ID3480
RRIDAB_2656386, AB_2656387, AB_2656388, AB_2656389, AB_2656390, AB_2656385

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CD221 (IGF-1R) Antibody, anti-human, REAfinity™

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