Clone:
REA198
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TEK, TIE-2, VMCM, VMCM1

Specifications for CD202b (TIE-2) Antibody, anti-human, REAfinity™

Overview

Clone REA198 recognizes CD202b, which is 145 kDa type I transmembrane tyrosine kinase receptor. CD202b is composed of an amino-terminal ligand binding domain with immunoglobulin domains, epithelial growth factor and fibronectin-like 3 repeats, a single transmembrane domain, and an intracellular tyrosine kinase domain. Expression of CD202b is found on endothelial cells and a subpopulation of monocytes. Angiopoietins are the natural ligands of CD202b and activation of CD202b dependent signaling pathways are involved in survival and apoptosis of endothelial cells, in controlling vascular permeability, and regulation of the capillary sprouting that occurs during normal angiogenesis.
Additional information: Clone REA198 displays negligible binding to Fc receptors.

Alternative names

TEK, TIE-2, VMCM, VMCM1

Detailed product information

Technical specifications

CloneREA198
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD202b (TIE-2)
Alternative names of antigenTEK, TIE-2, VMCM, VMCM1
Distribution of antigenendothelial cells, monocytes
RRIDAB_2656146, AB_2656147, AB_2656148, AB_2656149, AB_2656150, AB_2656151

References for CD202b (TIE-2) Antibody, anti-human, REAfinity™

Publications

  1. Murdoch, C. et al. (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol. 178: 7405-7411
  2. Sato, T. N. et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. U.S.A. 90: 9355-9358
  3. Schnurch, H. et al. (1993) Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development 119: 957-968

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