Clone:
REA156
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Specifications for PKCα Antibody, anti-human, REAfinity™

Overview

Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca
2+
handling in myocytes.
Additional information: Clone REA156 displays negligible binding to Fc receptors.

Alternative names

PRKCA, AAG6, PKC-alpha, PRKACA, PKC-A

Detailed product information

Technical specifications

CloneREA156
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitymouse, rat, dog, chicken
AntigenPKCα
Alternative names of antigenPRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
Molecular mass of antigen [kDa]77
Distribution of antigenother
Entrez Gene ID5578
RRIDAB_2889729, AB_2653209, AB_2653210, AB_2653211, AB_2653212, AB_2889730

Resources for PKCα Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for PKCα Antibody, anti-human, REAfinity™

Publications

  1. Koivunen, J. et al. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235(1): 1-10
  2. Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18(8): 2183
  3. Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78(2): 349-355

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