Clone:
REA251
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IHC, IF
Alternative names:
POU2F2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding transcription factor 2, Octamer-binding protein 2

Specifications for Oct-2 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA251 recognizes the Octamer-binding protein 2 (Oct-2) antigen, a transcription factor also known as POU domain class 2 transcription factor 2 (POU2F2). Oct-2 is expressed primarily in B lymphocytes and the developing central nervous system. It regulates gene transcription in a number of tissues in addition to activating immunoglobulin gene expression for normal humoral responses to T-dependent and T-independent antigens. Oct-2 binds to conserved sites in immunoglobulin variable gene promoters, several immunoglobulin gene enhancers and to sites in the promoters of other genes whose expression is B cell restricted. Once bound to a promoter, Oct-2 facilitates the assembly of the transcription initiation complex.
Additional information: Clone REA251 displays negligible binding to Fc receptors.

Alternative names

POU2F2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding transcription factor 2, Octamer-binding protein 2

Detailed product information

Technical specifications

CloneREA251
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenOct-2
Alternative names of antigenPOU2F2, OTF-2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding transcription factor 2, Octamer-binding protein 2
Molecular mass of antigen [kDa]51
Distribution of antigenB cells
Entrez Gene ID5452
RRIDAB_2653078, AB_2653079

Resources for Oct-2 Antibody, anti-human/mouse, REAfinity™

Certificates

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References for Oct-2 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Humbert, P. O. and Corcoran, L. M. (1997) Oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function. J. Immunol. 159(11): 5273-5284
  2. Müller-Immerglück, M. M. et al. (1990) Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells. EMBO J. 9(5): 1625-1634
  3. Clerc, R. G. et al. (1988) The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains. Genes Dev. 12: 1570-1581

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