Clone:
REAL790
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, NFH

Specifications for Neurofilament H (200 kD) Antibody, anti-human/mouse, REAdye_lease™

Overview

Clone REAL790 is an antibody fragment derived from the full Neurofilament H (200 kD) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL790 recognizes the Neurofilament H (200 kD) protein, which belongs to the type IV intermediate filament family. Neurofilaments are a major component of the neuronal cytoskeleton and a useful marker for distinguishing neurons which are positive for Neurofilament, from glia. It is found in several neural, neuroendocrine, and endocrine tumors, but also in carcinomas of skin and lung, paragangliomas and adrenal and extra-adrenal pheochromocytomas. Neurofilament H (200 kD) recognizes axons and some dendrites (except Purkinje cell dendrites) but not nerve cell bodies or tissues, except peripheral axons.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, NFH

Detailed product information

Technical specifications

CloneREAL790
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenNeurofilament H (200 kD)
Alternative names of antigenNeurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, NFH
Distribution of antigenneural cells, tumor cells

Resources for Neurofilament H (200 kD) Antibody, anti-human/mouse, REAdye_lease™

Certificates

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References for Neurofilament H (200 kD) Antibody, anti-human/mouse, REAdye_lease™

Publications

  1. Szaro, B. G. and Strong, M. J. (2010) Post-transcriptional control of neurofilaments: New roles in development, regeneration and neurodegenerative disease. Trends Neurosci. 33(1): 27-37
  2. Wang, H. et al. (2012) Neurofilament proteins in axonal regeneration and neurodegenerative diseases. Neural Regen. Res. 7(8): 620-626
  3. Basal, E. et al. (2018) Paraneoplastic neuronal intermediate filament autoimmunity. Neurology. 91(18): e1677-e1689

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