Clone:
REA398
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, IF, IHC
Alternative names:
MYL7, MYL2A, MYLC2A, MLC-2a

Specifications for MLC2a Antibody, anti-human/mouse/rat, REAfinity™

Overview

Clone REA398 recognizes the human, mouse, and rat atrial isoform of the myosin light chain 2 (MLC2a) antigen. Myosin is a hexamer composed of two myosin heavy chains and four myosin light chains. In the heart two different forms of the myosin light chain are expressed, the atrial form (MLC2a) and the ventricular form (MLC2v). MLC2a is expressed at high levels in atrial cardiomyocytes while MLC2v is essentially restricted to ventricular cardiomyocytes, albeit low levels of both MLC2a and MLC2v persist in the inflow tract, the atrioventricular canal, and the outflow tract of the heart during cardiogenesis. MLC2a expression may as well be suitable to identify mouse and human pluripotent stem cell–derived cardiomyocyte subtypes. 
Additional information: Clone REA398 displays negligible binding to Fc receptors.

Alternative names

MYL7, MYL2A, MYLC2A, MLC-2a

Detailed product information

Technical specifications

CloneREA398
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
AntigenMLC2a
Alternative names of antigenMYL7, MYL2A, MYLC2A, MLC-2a
Molecular mass of antigen [kDa]19
Distribution of antigenheart
Entrez Gene ID58498
RRIDAB_2751387, AB_2751549, AB_2751539, AB_2652933, AB_2652934, AB_2652941, AB_2652942, AB_2652943, AB_2751399

Resources for MLC2a Antibody, anti-human/mouse/rat, REAfinity™

Certificates

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References for MLC2a Antibody, anti-human/mouse/rat, REAfinity™

Publications

  1. Nishigaki, R. et al. (2002) An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Commun. 295(1): 112-118
  2. Hailstones, D. et al. (1992) Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. J. Biol. Chem. 267(32): 23295-23300
  3. Bizy, A. et al. (2013) Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes. Stem Cell Res. 11(3): 1335-1347

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