Clone:
REAL176
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC
Alternative names:
Ly-6G.1, Ly6g

Specifications for Ly-6G Antibody, anti-mouse,
REAlease
®

Overview

Clone REAL176 is an antibody fragment derived from the full Ly-6G antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL176 recognizes the mouse Ly-6G (Lymphocyte antigen 6G) antigen, a 21-25-kDa glycosylphosphatidylinositol (GPI) linked protein which is highly expressed on neutrophilic granulocytes. Expression greatly increases during granulocyte maturation. To a lower extent, Ly-6G is also expressed during the development of monocytes. In mouse bone marrow samples, Ly-6G is primarily detected on granulocytes, but not on lymphocytes or erythrocytes. Ligation of Ly-6G in animals with an underlying background inflammation (induced by TNF-α) leads to profound cardiovascular and respiratory responses, including severe breathing difficulties, leukocyte and platelet aggregation, and coagulation, leading to microvessel obstruction and subsequent death.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Ly-6G.1, Ly6g

Detailed product information

Technical specifications

CloneREAL176
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenLy-6G
Alternative names of antigenLy-6G.1, Ly6g
Distribution of antigengranulocytes, monocytes, macrophages

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