Clone:
REA1042
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CD158A

Specifications for KIR2D Antibody, anti-human, REAfinity™

Overview

Clone REA1042 recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).
Additional information: Clone REA1042 displays negligible binding to Fc receptors.

Alternative names

CD158A

Detailed product information

Technical specifications

CloneREA1042
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenKIR2D
Alternative names of antigenCD158A
Molecular mass of antigen [kDa]31-39
Distribution of antigenNK cells, T cells, CD8+ T cells
Entrez Gene ID3806, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292, 100132285
RRIDAB_2733677, AB_2733872, AB_2733873, AB_2733429, AB_2733430, AB_2733964, AB_2733965, AB_2734104, AB_2734105, AB_2733002, AB_2733003, AB_2733268, AB_2733269, AB_2733156, AB_2733057, AB_2733058, AB_2734041, AB_2734042, AB_2733554, AB_2733555, AB_2733676

Resources for KIR2D Antibody, anti-human, REAfinity™

References for KIR2D Antibody, anti-human, REAfinity™

Publications

  1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
  2. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52

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