Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Extended validation for Jak1 Antibody, anti-human/mouse/rat, REAfinity™


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA700
Cells were incubated with an excess of purified unconjugated Jak1 (REA700) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for Jak1 Antibody, anti-human/mouse/rat, REAfinity™


Clone REA700 recognizes the human, mouse, and rat Jak1 antigen, also known as tyrosine-protein kinase JAK1 or janus kinase 1. Jak1 is a widely expressed membrane-associated phosphoprotein characterized by the presence of a second phosphotransferase-related domain immediately N terminal to the PTK domain. Jak1 is involved in the IFN-α/β/γ signal pathway and activates transcription factors of the STAT family by phosphorylating critical tyrosine regulatory sites.
Additional information: Clone REA700 displays negligible binding to Fc receptors

Alternative names

Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
Alternative names of antigenTyrosine-protein kinase JAK1, Janus kinase 1, JAK-1
Molecular mass of antigen [kDa]133(same molecular weight for human and mouse/rat)
Distribution of antigenubiquitous
Entrez Gene ID3716, 16451, 84598
RRIDAB_2652545, AB_2652546, AB_2652547, AB_2652544

Resources for Jak1 Antibody, anti-human/mouse/rat, REAfinity™


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References for Jak1 Antibody, anti-human/mouse/rat, REAfinity™


  1. Wilks, A. F. et al. (1991) Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell. Biol. 11(4): 2057-2065
  2. Williams, N. K. et al. (2009) Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase Domains. J. Mol. Biol. 387(1): 219-232

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