Clone:
REA1036
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
JAG2, HJ2, SER2

Specifications for Jagged2 Antibody, anti-human, REAfinity™

Overview

Clone REA1036 recognizes the human Jagged2 protein, which is one of the several mammalian Notch ligands. Jagged2 is expressed by various organs and cell types and is involved in regulation of cell differentiation processes, such as lymphocyte development, myogenesis, and neurogenesis. Jagged2 is reported to be essential for the regulation of spermatogenesis. Jagged2 is also expressed on some lymphoma and leukemia cells and various other tumor cells and can be expressed by various antigen-presenting cells (APC) and may contribute to APC-directed peripheral T cell differentiation.
Additional information: Clone REA1036 displays negligible binding to Fc receptors

Alternative names

JAG2, HJ2, SER2

Detailed product information

Technical specifications

CloneREA1036
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenJagged2
Alternative names of antigenJAG2, HJ2, SER2
Molecular mass of antigen [kDa]131
Distribution of antigentumor cells, antigen-presenting cells, leukemia cells, lymphoma, tumor
Entrez Gene ID3714
RRIDAB_2728003, AB_2727952, AB_2728004, AB_2727953, AB_2728005, AB_2727954, AB_2728006, AB_2727955, AB_2728007, AB_2727956, AB_2728008, AB_2727957

Resources for Jagged2 Antibody, anti-human, REAfinity™

Certificates

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References for Jagged2 Antibody, anti-human, REAfinity™

Publications

  1. Luo, B. et al. (1997) Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol. Cell. Biol. 17(10): 6057-6067
  2. Passos, G. S. et al. (2006) Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. Schizophr. Res. 88(1–3): 275-282

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