Clone:
REA517
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MHC class I HLA-A2

Specifications for HLA-A2 Antibody, anti-human, REAfinity™

Overview

Clone REA517 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA517 displays negligible binding to Fc receptors.

Alternative names

MHC class I HLA-A2

Detailed product information

Technical specifications

CloneREA517
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenHLA-A2
Alternative names of antigenMHC class I HLA-A2
Molecular mass of antigen [kDa]38
Distribution of antigenother
Entrez Gene ID3105
RRIDAB_2751591, AB_2727641, AB_2727568, AB_2751639, AB_2751593, AB_2784362, AB_2784361, AB_2811492, AB_2811481, AB_2857613, AB_2857601, AB_2652065, AB_2652066, AB_2751637

Resources for HLA-A2 Antibody, anti-human, REAfinity™

Certificates

Please follow this
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References for HLA-A2 Antibody, anti-human, REAfinity™

Publications

  1. Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329(6139): 506-512
  2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
  3. Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425(22): 4496-4507

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