Clone:
REA116
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
TBR-2

Specifications for EOMES Antibody, anti-mouse, REAfinity™

Overview

Clone REA116 recognizes EOMES, also known as T-box brain protein 2 (TBr2) or eomesodermin. EOMES is a 72–74 kDa T-box transcription factor and plays a crucial role in development including trophoblast differentiation, gastrulation, brain development, and cell-mediated immunity in adults. EOMES lacking embryos are arrested at the blastocyst stage due to differentiation defects of the trophoectoderm. As a regulator of cell mediated immunity, expression of EOMES is shown to be increased in effector CD8
+
T cells, in response to infection. Further, EOMES including its paralogue T-bet are suggested to be involved in NK cell maturation.
Additional information: Clone REA116 displays negligible binding to Fc receptors.

Alternative names

TBR-2

Detailed product information

Technical specifications

CloneREA116
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenEOMES
Alternative names of antigenTBR-2
Molecular mass of antigen [kDa]75
Entrez Gene ID13813
RRIDAB_2651632, AB_2651633, AB_2651634, AB_2651635

Resources for EOMES Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for EOMES Antibody, anti-mouse, REAfinity™

Publications

  1. Gordon, S. M. et al. (2012) The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 36(1): 55-67
  2. Pearce, E. L. et al. (2003)
    Control of effector CD8
    +
    T cell function by the transcription factor Eomesodermin.
    Science 302: 1041
  3. Kidder, B. L. et al. (2010) Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 20: 458-472

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