Clone:
REA1316
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
ADPRT, PARP, PPOL, PARP-1, ARTD1

Specifications for Cleaved PARP1 Antibody, anti-human, REAfinity™

Overview

Clone REA1316 recognizes the human PARP1 enzyme, Poly (ADP-ribose) polymerase 1, that modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 plays a role in DNA repair in response to environmental stress, genomic stability, and programmed cell death. It catalyzes the transfer of ADP-ribose units from NAD
+
to a variety of nuclear proteins including topoisomerases, histones, and PARP itself. PARP1 is involved in differentiation, proliferation and tumor transformation. Furthermore PARP can be cleaved by many ICE-like caspases, it is a cleavage- target of the caspase-3 protease activity associated with apoptosis. Cancer tissues express PARP1 to a high extent, including neuroblastoma, testicular and other germ cell tumors, malignant lymphoma and breast and colon cancer.
Additional information: Clone REA1316 displays negligible binding to Fc receptors.

Alternative names

ADPRT, PARP, PPOL, PARP-1, ARTD1

Detailed product information

Technical specifications

CloneREA1316
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCleaved PARP1
Alternative names of antigenADPRT, PARP, PPOL, PARP-1, ARTD1
Distribution of antigenubiquitous, tumor cells

Resources for Cleaved PARP1 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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