Clone:
REA304
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IHC, IF
Alternative names:
B-cell activation protein, Cell surface protein HB15

Specifications for CD83 Antibody, anti-mouse, REAfinity™

Overview

Clone REA304 recognizes the mouse CD83 antigen, a Single-pass type I membrane protein which belongs to the immunoglobulin superfamily. Murine CD83 is moderately expressed on resting T cells and DC, but strongly increases in its expression on T cells following activation with antigenic peptides or T cell receptor-specific monoclonal antibody. When returning to the resting state, T cells down-regulate CD83 again. Histological analysis of serial spleen sections revealed a CD83 expression pattern resembling that of MIDC-8, a known murine DC marker molecule.
Additional information: Clone REA304 displays negligible binding to Fc receptors.

Alternative names

B-cell activation protein, Cell surface protein HB15

Detailed product information

Technical specifications

CloneREA304
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD83
Alternative names of antigenB-cell activation protein, Cell surface protein HB15
Molecular mass of antigen [kDa]19
Distribution of antigendendritic cells, T cells, spleen
Entrez Gene ID12522
RRIDAB_2659309, AB_2659310, AB_2659311, AB_2659312, AB_2659313, AB_2659314, AB_2659315, AB_2659316, AB_2659317, AB_2659307, AB_2659308, AB_2659306

Resources for CD83 Antibody, anti-mouse, REAfinity™

Certificates

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References for CD83 Antibody, anti-mouse, REAfinity™

Publications

  1. Lüthje, K. et al. (2008) CD83 regulates splenic B cell maturation and peripheral B cell homeostasis. Int. Immunol. 20(8): 949-960
  2. Twist, C. J. et al. (1998) The mouse CD83 gene: structure, domain organization, and chromosome localization. Immunogenetics 48(6): 383-393
  3. Wolenski, M. et al. (2003) Expression of CD83 in the murine immune system. Med. Microbiol. Immun. 192(4): 189-192

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