Clone:
REAL174
Type of antibody:
Releasable antibodies, Primary antibodies, Recombinant antibodies
Applications:
FC
Alternative names:
Ly-1, Ly-12, Ly-A, Lyt-1, T1, Tp67

Specifications for CD5 Antibody, anti-mouse,
REAlease
®

Overview

Clone REAL174 is an antibody fragment derived from the full CD5 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL174 recognizes the mouse CD5 antigen, a 67 kDa single-pass type I membrane protein which is also known as lymphocyte antigen 1 (Ly-1). CD5 is expressed by a majority of thymocytes, mature T cells, and a subset of B cells. The expression of CD5 by a small B cell subset characterizes a developmentally and functionally distinct lineage of B cells called B-1a cells. CD5 plays a role in the interaction of T and B cells and is a counter-receptor for CD72.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Ly-1, Ly-12, Ly-A, Lyt-1, T1, Tp67

Detailed product information

Technical specifications

CloneREAL174
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable antibodies, Primary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD5
Alternative names of antigenLy-1, Ly-12, Ly-A, Lyt-1, T1, Tp67
Distribution of antigenthymic epithelial cells, T cells, B cells
RRIDAB_2751293, AB_2784244, AB_2784245, AB_2751690

Resources for CD5 Antibody, anti-mouse,
REAlease
®

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD5 Antibody, anti-mouse,
REAlease
®

Publications

  1. Tarakhovsky, A. et al. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269(5223): 535-537
  2. Efanov, A. et al. (2010)
    CD5
    +
    CD23
    +
    leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation.
    Leukemia 24(5): 970-975
  3. Lundy, S. K. et al. (2014)
    Characterization and activity of Fas ligand producing CD5
    +
    B cells.
    Methods Mol. Biol. 1190: 81-102

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REAlease
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