Clone:
REA639
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC

Extended validation for CD45RA Antibody, anti-mouse, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA639
14.8+
Cells were incubated with an excess of purified unconjugated CD45RA (REA639) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD45RA Antibody, anti-mouse, REAfinity™

Overview

Clone REA639 recognizes the exon A-dependent epitope CD45RA in mouse, one of eight isoforms of the transmembrane glycoprotein CD45, which is a member of the protein tyrosine phosphatase (PTP) family. CD45RA is expressed highly on B cells, weakly on CD8
+
T cells, and nearly on all B cell–lineages but it is not detectable on hematopoietic stem cells or myeloid progenitors.
Additional information: Clone REA639 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA639
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD45RA
Molecular mass of antigen [kDa]135
Distribution of antigenT cells, B cells
Entrez Gene ID19264
RRIDAB_2658322, AB_2658323, AB_2658326, AB_2658327, AB_2658328, AB_2658329, AB_2658330, AB_2658331, AB_2658332, AB_2658333, AB_2658334, AB_2658335, AB_2658336, AB_2658337, AB_2905026, AB_2784219

Resources for CD45RA Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD45RA Antibody, anti-mouse, REAfinity™

Publications

  1. Hathcock, K. S. et al. (1992) Expression of variable exon A-, B-, and C-specific CD45 determinants on peripheral and thymic T cell populations. J. Immunol. 148: 19-28
  2. Inoue, T. et al. (1993)
    Distinction of mouse CD8
    +
    suppressor effector T cell clones from cytotoxic T cell clones by cytokine.
    J. Immunol. 150: 2121-2128

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